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Nanogels for delivery, imaging and therapy.

Amal J Sivaram1, P Rajitha2, S Maya1

  • 1Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.

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Nanogels, nanoscale hydrogels, offer versatile drug delivery solutions. Their stimuli-responsive properties enable controlled release for cancer, inflammation, and protein therapies.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Nanogels are cross-linked polymer networks in the nanometer size range.
  • They offer advantages like stimuli-responsiveness, high drug loading, and stability.

Purpose of the Study:

  • To review the diverse applications of nanogels in drug delivery.
  • To highlight their potential in targeted therapies and improving drug efficacy.

Main Methods:

  • Review of existing literature on nanogel synthesis and applications.
  • Analysis of nanogel properties relevant to drug delivery.

Main Results:

  • Nanogels demonstrate significant potential in cancer, anti-inflammatory, and protein/peptide drug delivery.
  • Their stimuli-responsive nature is crucial for targeted delivery in disease states.
  • Muco-adhesive nanogels enhance ocular drug availability, while others improve transdermal penetration.

Conclusions:

  • Nanogels are highly versatile platforms for advanced drug delivery systems.
  • Their unique properties facilitate controlled release, enhanced stability, and targeted therapeutic outcomes.