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In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
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Chronic traumatic encephalopathy: historical origins and current perspective
Philip H Montenigro1, Daniel T Corp, Thor D Stein
1Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, Massachusetts 02118; email: valmont@bu.edu , tdstein@bu.edu , bobstern@bu.edu.
Annual Review of Clinical Psychology
|January 13, 2015
Summary
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive head impacts. This review covers CTE
Area of Science:
- Neuroscience
- Neuropathology
- Clinical Neurology
Background:
- Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease primarily diagnosed postmortem.
- It is associated with repetitive head impacts common in athletes like boxers and football players.
Observation:
- CTE neuropathology involves unique hyperphosphorylated tau protein accumulation.
- Clinical manifestations include progressive mood, behavior, and cognitive changes, often leading to dementia.
- Motor symptoms like parkinsonism can also occur.
Findings:
- This review details the historical origins and current understanding of CTE.
- It covers neuropathology, clinical features, diagnostic criteria, biomarkers, risk factors, and treatments.
Implications:
- Understanding CTE is crucial for diagnosing and managing neurodegenerative conditions in at-risk populations.
- Further research into in vivo biomarkers and treatments is essential for early detection and intervention.
- This review provides a comprehensive overview for researchers and clinicians.
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