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Liver Histology

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Histopathologic variation between liver lobes in dogs.

S D Kemp¹, K L Zimmerman, D L Panciera

¹Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA.

Journal of Veterinary Internal Medicine

|January 13, 2015

Summary

Biopsying multiple liver lobes in dogs increases the accuracy of diagnosing liver disease. This study found that examining several liver lobes improves the identification of the predominant histopathologic abnormality.

Keywords:

Fibrosis Hepatitis Liver biopsy

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Area of Science:

Veterinary Pathology
Comparative Pathology
Canine Histopathology

Background:

Liver biopsy is crucial for diagnosing organ-wide disease, but inferences are made from small samples.
Current recommendations for canine liver biopsy often involve multiple lobes, yet lobe-to-lobe consistency is unestablished.

Purpose of the Study:

To determine the distribution of histopathologic abnormalities across different liver lobes in dogs.
To test the hypothesis that discordant histopathologic findings are evenly distributed among liver lobes.

Main Methods:

A prospective study involving necropsy of seventy dogs.
Histopathologic evaluation of liver samples collected from all lobes of each dog.
Assignment of a primary diagnosis based on the predominant abnormality in each liver sample.

Main Results:

Biopsy of at least two liver lobes identified the predominant abnormality in 98.6% of cases.
In 14% of dogs, fewer than four lobes agreed, preventing a predominant diagnosis.
Histopathologic diagnoses showed concordance across lobes, with no significant difference in discordant results between lobes.

Conclusions:

Biopsying multiple liver lobes significantly enhances the probability of obtaining a representative sample.
This approach improves the accuracy of diagnosing the predominant histologic abnormality in canine liver disease.