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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Hispanics and inflammatory bowel disease.

Lakshmi D N Lattimer1, Matthew B Chandler, Marie L Borum

  • 1Department of Medicine, Division of Gastroenterology, George Washington University, Washington, DC.

Inflammatory Bowel Diseases
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Inflammatory bowel disease (IBD) affects diverse populations, including Hispanics. Research shows environmental factors may influence IBD subtypes in U.S.-born versus foreign-born Hispanics, with potential disparities in treatment use.

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Area of Science:

  • Gastroenterology
  • Epidemiology
  • Health Disparities

Background:

  • Historically, inflammatory bowel disease (IBD) research has focused on White populations.
  • Shifting demographics in the U.S. highlight the need to understand IBD in Hispanic populations.
  • Current literature on IBD in Hispanics is limited.

Purpose of the Study:

  • To review existing literature on inflammatory bowel disease (IBD) in Hispanic populations.
  • To identify knowledge gaps regarding IBD prevalence, disease subtypes, and treatment in Hispanics.

Main Methods:

  • A comprehensive PubMed search was conducted.
  • Keywords included "inflammatory bowel disease," "Ulcerative Colitis," "Crohn's disease," "Hispanics," "Latinos," and "ethnicity."
  • Only English-language articles focusing on adult populations were included.

Main Results:

  • Data on Hispanic patients with IBD is sparse.
  • IBD prevalence may be higher in U.S. Hispanics compared to Latin America.
  • Conflicting data exists on ulcerative colitis vs. Crohn's disease prevalence; environmental factors may influence subtypes.
  • U.S.-born Hispanics show Crohn's disease patterns similar to non-Hispanic Whites.
  • A trend of decreased biologic and immunomodulator use in Hispanics was observed.

Conclusions:

  • Further research is essential to understand IBD in diverse Hispanic subgroups (U.S.-born vs. foreign-born).
  • Investigating the causes of potential disparities in biologic and immunomodulator use among Hispanics is crucial.