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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
The correlation between the ankle-brachial index and the metabolic syndrome.
F Mitu1, O Mitu, Maria-Magdalena Leon
1University of Medicine and Pharmacy Grigore T. Popa - Iaşi, Department of Medical Specialties (I).
Insights
The ankle-brachial index effectively predicts cardiovascular disease risk, especially in patients with metabolic syndrome. Routine measurement can aid early diagnosis of atherosclerosis and high-risk individuals.
Area of Science:
- Vascular Medicine
- Cardiology
- Public Health
Background:
- Cardiovascular diseases (CVDs) are a leading cause of global mortality and disability.
- Atherosclerosis is a primary etiological factor, with lower limb artery involvement indicating potential systemic vascular disease.
- Metabolic syndrome and conventional risk factors significantly contribute to CVD development.
Purpose of the Study:
- To evaluate correlations between ankle-brachial index (ABI) levels and cardiovascular risk factors.
- To assess the relationship between ABI and metabolic syndrome.
- To determine ABI's predictive value for cardiovascular disease.
Main Methods:
- Ankle-brachial index (ABI) values categorized as normal or abnormal.
- Evaluation of cardiovascular risk factors including age, sex, hypertension, obesity, smoking, dyslipidemia, and hyperglycemia.
- Statistical analysis to compare ABI groups and identify correlations.
Main Results:
- Significant statistical differences in ABI values were observed between normal and abnormal groups, particularly in patients with diabetes mellitus and metabolic syndrome.
- The ankle-brachial index was found to be considerably lower in patients diagnosed with metabolic syndrome.
- ABI demonstrated a strong association with metabolic syndrome and diabetes.
Conclusions:
- Ankle-brachial index measurement serves as an independent predictor of cardiovascular disease development, beyond metabolic syndrome and conventional risk factors.
- ABI is a valuable atherosclerosis marker for lower limb arteries.
- Routine ABI measurement in clinical practice can facilitate early diagnosis of high-risk cardiovascular disease patients.
Unlabelled:
On a global scale, the cardiovascular diseases constitute the prime factor of death and invalidity. The premature mortality percentage caused by these varies from 4% in high developed countries to 40% in underdeveloped countries. Atherosclerosis is the most important etiological factor. The presence of various degrees of atherosclerosis in a certain vascular area (in our case, the lower limb arteries), increases the probability of affecting other areas as well (coronary, cerebral, renal, mesenteric arteries).
Aim:
The evaluation and description of the correlations between the ankle-brachial index levels and the cardiovascular risk factors, taken individually or as part of the metabolic syndrome.
Material And Method:
The values of the ankle-brachial index were divided in normal and abnormal. The evaluated cardiovascular risk factors were: age, sex, arterial hypertension, obesity, smoking, high levels of cholesterol and basal glucose, low levels of HDL-cholesterol.
Results:
There were significant statistical differences between the normal ankle-brachial index lot and the one with abnormal values, specifically in patients with diabetes mellitus and metabolic syndrome. More so, the study demonstrates that the ankle-brachial index is considerably smaller in patients with metabolic syndrome.
Conclusions:
The simple measurement of the afore mentioned index, as a atherosclerosis marker for the lower limb arteries, represents an independent prediction over the metabolic syndrome and the conventional risk factors, in the development of the cardiovascular diseases. The routine measurement of this parameter in medical practice might imply the early diagnosis of high risk manifested cardiovascular disease patients.
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