New platforms for multi-functional ocular lenses: engineering double-sided functionalized nano-coatings

Area of Science:

• Biomaterials Science
• Nanotechnology
• Ophthalmology

Background:

• Ocular drug delivery faces challenges with conventional methods, including poor bioavailability and frequent administration.
• Developing advanced ocular devices for sustained and targeted drug release is crucial for treating eye conditions.

Purpose of the Study:

• To demonstrate a scalable platform for preparing multi-functional ocular lenses with tailored drug encapsulation.
• To utilize electrohydrodynamic atomization (EHDA) for precise, side-specific coating of ocular lenses with therapeutic agents.

Main Methods:

• A modified, scaled-up masking electrohydrodynamic atomization (EHDA) technique was employed for coating ocular lenses.
• Rapidly dissolving polyvinylpyrrolidone (PVP) was used as the stabilizing matrix for nanoparticle and nanofiber encapsulation.
• A flip-able well design allowed selective, side-specific coating of ocular lenses with different drug substances and morphologies.

Main Results:

• PVP nanoparticles (<100 nm) with a fluorescent probe were coated on the inner lens side, and PVP nanofibers (<200 nm) with chloramphenicol were coated on the outer side.
• Demonstrated rapid release of the probe and antimicrobial activity against Staphylococcus aureus, confirming drug efficacy.
• The process was achieved at ambient temperature and pressure, highlighting its practicality and scalability.

Conclusions:

• The developed EHDA platform offers a scalable and versatile method for creating multi-functional ocular lenses.
• This technology enables personalized drug delivery, nanomedicine applications, and the development of nanosensors within a single device.
• Future adaptations can lead to advanced therapeutic platforms for various ocular conditions.