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Published on: June 30, 2018
Laboratory identification of donor-derived coxsackievirus b3 transmission
I J Abbott1, G Papadakis, M Kaye
1Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia.
Abstract:
Unexpected donor-to-recipient infectious disease transmission is an important, albeit rare, complication of solid organ transplantation. Greater work and understanding about the epidemiology of these donor-derived transmissions is continually required to further mitigate this risk. Herein we present the first reported case of proven donor-derived transmission of coxsackievirus serogroup-3, an enterovirus, following solid organ transplant. Swift and effective communication between the organ donation agency, treating physicians, laboratory testing and notification ensured a coordinated approach. The resulting clinical syndromes in the organ recipients were mild. This case highlights the requirement for ongoing surveillance over a broad range of infecting pathogens that may present as a donor-derived infection.
Insights
Donor-derived infectious disease transmission is a rare solid organ transplant risk. This case details the first proven transmission of coxsackievirus serogroup-3, an enterovirus, with mild recipient outcomes.
Area of Science:
- Infectious Diseases
- Transplantation Immunology
- Virology
Background:
- Donor-to-recipient infectious disease transmission is a rare but significant complication in solid organ transplantation.
- Understanding the epidemiology of these transmissions is crucial for risk mitigation strategies.
Observation:
- This report details the first documented case of proven donor-derived transmission of coxsackievirus serogroup-3, a type of enterovirus.
- The transmission occurred following a solid organ transplant procedure.
Findings:
- Swift communication among organ donation agencies, physicians, and laboratories facilitated a coordinated response.
- The clinical syndromes observed in the organ recipients were mild, despite the viral transmission.
Implications:
- This case underscores the necessity for continuous surveillance of a wide spectrum of potential pathogens that could be transmitted from donors.
- Enhanced vigilance and diagnostic capabilities are essential to prevent and manage donor-derived infections in transplant recipients.
