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Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...

Position-effect Variegation

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.

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Related Experiment Video

Updated: Apr 18, 2026

Single Oocyte Bisulfite Mutagenesis

Single Oocyte Bisulfite Mutagenesis

Published on: June 27, 2012

Corrigendum for "Dissecting genetic effects with imprinting".

José M Álvarez-Castro¹

¹Department of Genetics, Universidade de Santiago de Compostela Lugo, Spain.

Frontiers in Genetics

|January 14, 2015

Summary

This summary is machine-generated.

This article provides a correction to a previously published study. It ensures the accuracy of the Digital Object Identifier and publication details for the research. This correction is vital for proper citation and retrieval of scientific literature.

Keywords:

NOIA genetic variance decomposition imprinting individual-referenced models of genetic effects population-referenced models of genetic effects

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Last Updated: Apr 18, 2026

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Area of Science:

Ecology and Evolutionary Biology
Scientific Publishing

Context:

Correction of previously published scientific article details.
Ensuring accurate referencing and citation for research integrity.

Purpose:

To amend the Digital Object Identifier (DOI) for the article.
To correct specific page and volume information for accurate record-keeping.

Summary:

The article corrects the DOI associated with a published study.
It also rectifies page and volume number errors for precise identification.

Impact:

Improves the discoverability and retrievability of the scientific work.
Upholds the standards of accuracy and reliability in scientific communication.