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Total synthesis of trioxacarcin DC-45-A2
K C Nicolaou1, Quan Cai, Bo Qin
1Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA). kcn@rice.edu.
Angewandte Chemie (International Ed. in English)
|January 14, 2015
Abstract:
An enantioselective total synthesis of trioxacarcin DC-45-A2 (1) featuring a novel Lewis acid-induced cascade rearrangement of epoxyketone 6 to forge the polyoxygenated 2,7-dioxabicyclo[2.2.1]heptane core of the molecule is described.