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SAffold viruses in pediatric patients with diarrhea in Thailand

Arpaporn Yodmeeklin1, Pattara Khamrin, Watchaporn Chuchaona

  • 1Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Journal of Medical Virology
|January 14, 2015
PubMed

Insights

Saffold virus (SAFV) was detected in 1.5% of pediatric diarrhea cases in Thailand. Four SAFV genotypes were identified, highlighting the virus

Area of Science:

  • Virology
  • Gastroenterology
  • Public Health

Background:

  • Saffold virus (SAFV), a member of the Cardiovirus genus within the Picornaviridae family, is a recently identified human pathogen.
  • Understanding the prevalence and genetic diversity of emerging viruses like SAFV is crucial for public health surveillance.

Purpose of the Study:

  • To investigate the presence and genetic characteristics of Saffold virus in fecal samples from children with diarrhea in Thailand.
  • To identify the genotypes of SAFV circulating in this pediatric population.

Main Methods:

  • RT-nested PCR and sequence analysis were employed to detect and characterize SAFV.
  • Fecal specimens were collected from 608 children experiencing diarrhea in Chiang Mai, Thailand, between January 2012 and December 2013.

Main Results:

  • SAFV was detected in 9 out of 608 (1.5%) fecal specimens.
  • Four distinct SAFV genotypes (SAFV1, SAFV2, SAFV3, and SAFV4) were identified.
  • SAFV mono-infection occurred in five cases, while co-infection with other diarrheal pathogens was observed in four cases.

Conclusions:

  • This study confirms the circulation of Saffold virus in Thailand among children with diarrhea.
  • The identification of multiple SAFV genotypes provides valuable insights into the genetic diversity of this emerging virus in the region.
  • Further research is warranted to understand the clinical significance and transmission dynamics of SAFV in pediatric populations.

Keywords:
Saffold virusThailandchildrendiarrhea

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