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Updated: Apr 18, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
Lung cancer screening, version 1.2015: featured updates to the NCCN guidelines
Douglas E Wood1, Ella Kazerooni1, Scott L Baum1
1From University of Washington/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; University of Alabama at Birmingham Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Dana-Farber/Brigham and Women's Cancer Center; Moffitt Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center at The Nebraska Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; Stanford Comprehensive Cancer Center; UC San Diego Moores Cancer Center; Vanderbilt-Ingram Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Huntsman Cancer Institute at the University of Utah; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; University of Colorado Cancer Center; Massachusetts General Hospital Cancer Center; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.
Abstract:
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide recommendations for selecting individuals for lung cancer screening, and for evaluation and follow-up of nodules found during screening, and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights focus on the major updates to the 2015 NCCN Guidelines for Lung Cancer Screening, which include a revision to the recommendation from category 2B to 2A for one of the high-risk groups eligible for lung cancer screening. For low-dose CT of the lung, the recommended slice width was revised in the table on "Low-Dose Computed Tomography Acquisition, Storage, Interpretation, and Nodule Reporting."
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