PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk

Montse Guardiola¹, Holly J Exeter², Claire Perret²+16

• ¹From the Center for Cardiovascular Genetics, Institute of Cardiovascular Science (M.G., H.J.E., J.P., K.W.L., J.A.C., S.E.H., P.J.T.), and Genetic Epidemiology Group, Department of Epidemiology and Public Health (M.V.H.), University College London, London, UK; Unitat de Recerca en Lípids i Arteriosclerosi, Universitat Rovira i Virgili, CIBERDEM, IISPV, Reus, Spain (M.G.); Genomics and Pathophysiology of Cardiovascular Diseases Team, ICAN, Sorbonne Universités, UPMC University Paris 06, INSERM UMR_S 1166, Paris, France (C.P., E.N.); Molecular Genetics Department, Novo Nordisk A/S, Copenhagen, Denmark (L.F.); Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden (L.F., F.v.H., P.E., G.P.-B.); Atherosclerosis Research Unit, Department of Medicine Solna (F.v.H., P.E.), and Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (A.F.-C.), Karolinska Institutet, Stockholm, Sweden; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge (K.-T.K.); Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, England, UK (Z.M.); Sorbonne Universités, UPMC Univ Paris 06 (S.-A.K.), and Physiopathology of Genetic Diseases With Pediatric Expression, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933, Paris, France (S.-A.K.); Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands (S.M.B.); and Department of Surgery and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.V.H.). montse.guardiola@urv.cat.+1