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Updated: Apr 18, 2026

Animal Models of Depression - Chronic Despair Model CDM
Published on: September 23, 2021
Effects of chronic disease self-management programs for participants with higher depression scores: secondary
Philip L Ritter1, Marcia G Ory2, Diana D Laurent1
1Stanford Patient Education Research Center, School of Medicine, Stanford University, 1000 Welch Road Rd., Suite 204, Palo Alto, CA 94304 USA.
Abstract:
Depression often accompanies chronic illness. Study aims included determining (1) the level of current depression (Patient Health Questionnaire (PHQ)-8 ≥ 10) for two sets of Chronic Disease Self-Management Programs (CDSMP) participants; (2) if depression or other outcomes improved for those with PHQ-8 ≥ 10; and (3) if outcomes differed for participants with or without depression. This study utilized longitudinal secondary data analysis of depression cohorts (PHQ-8 ≥ 10) from two independent translational implementations of the CDSMP, small-group (N = 175) and Internet-based (N = 110). At baseline, 27 and 55 % of the two samples had PHQ-8 10 or greater. This decreased to 16 and 37 % by 12 months (p < 0.001). Both depressed and non-depressed cohorts demonstrated improvements in most 12-month outcomes (pain, fatigue, activity limitations, and medication adherence). The CDSMP was associated with long-term improvements in depression regardless of delivery mode or location, and the programs appeared beneficial for participants with and without depression.
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