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Related Experiment Video

Updated: Apr 18, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

Deformability-based red blood cell separation in deterministic lateral displacement devices-A simulation study.

Timm Krüger¹, David Holmes², Peter V Coveney³

¹Institute for Materials and Processes, School of Engineering, University of Edinburgh , The King's Buildings, Edinburgh EH9 3JL, Scotland.

Biomicrofluidics

|January 14, 2015

Summary

This summary is machine-generated.

Deterministic lateral displacement (DLD) devices can separate red blood cells (RBCs) based on their deformability. This breakthrough allows predicting cell displacement, aiding disease detection without complex sample preparation.

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Last Updated: Apr 18, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

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Author Spotlight: Studying Biomechanics of Circulating Cells by Modulating Their Electrodeformation Behavior

Author Spotlight: Studying Biomechanics of Circulating Cells by Modulating Their Electrodeformation Behavior

Published on: October 13, 2023

Area of Science:

Biophysics
Microfluidics
Cellular mechanics

Background:

Red blood cell (RBC) deformability is altered by diseases like malaria.
Current disease detection methods for RBCs often require extensive sample preparation.
Microfluidic devices offer potential for label-free cell analysis.

Purpose of the Study:

To investigate the feasibility of separating red blood cells (RBCs) based on deformability using deterministic lateral displacement (DLD) devices.
To establish a predictive model for RBC displacement within DLD geometries based on cellular deformability.
To explore the potential of DLD devices for disease detection through RBC deformability fingerprinting.

Main Methods:

Three-dimensional immersed-boundary-finite-element-lattice-Boltzmann simulations were employed.
Simulations focused on the interaction of RBCs with DLD device geometries.
Analysis centered on deformability-dependent lateral extension of RBCs.

Main Results:

Demonstrated that RBC separation is achievable in DLD devices solely based on cell deformability.
Established a correlation between RBC deformability and their lateral extension within the DLD.
Developed the capability to predict which RBCs will be displaced in a given DLD setup.

Conclusions:

Deformability-based RBC separation in DLD devices is a viable approach.
This method allows for a priori prediction of cell behavior, facilitating device design.
Findings support the development of microfluidic diagnostic tools for diseases affecting RBC deformability.