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Area of Science:

  • Microfluidics
  • Materials Science
  • Biomedical Engineering

Background:

  • Paper-based microfluidic devices offer a low-cost platform for diagnostics.
  • Precise control over fluid flow is crucial for multiplexed assays and sequential reactions.
  • Existing methods for flow control can be complex or expensive.

Purpose of the Study:

  • To introduce a simple, pressure-based method for controlling fluid flow in paper microfluidic devices.
  • To characterize the relationship between applied pressure and flow rate reduction.
  • To demonstrate the utility of this method in sequential fluid delivery and immunoassays.

Main Methods:

  • Applying mechanical pressure to the paper substrate to reduce pore size and permeability.
  • Characterizing flow velocity changes under varying pressure conditions.
  • Integrating the pressure-based flow control into Y-shaped and multi-branched paper devices.

Main Results:

  • Achieved up to a 740% decrease in fluid velocity through applied pressure.
  • Demonstrated controlled fluid flow in Y-shaped and multi-branched paper devices.
  • Successfully performed sequential delivery of multiple fluid samples for a multi-step immunoassay, yielding a 4.3-fold signal increase.

Conclusions:

  • Pressure-induced modification of paper substrate is an effective strategy for fluid flow control in microfluidic devices.
  • This method enables precise sequential sample delivery, enhancing applications like multi-step colorimetric immunoassays.
  • The simplicity and low cost of this technique make it suitable for point-of-care diagnostics.