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Evaluation of Pre-Malignant and Malignant Lesions in Cervico Vaginal (PAP) Smears by Nuclear Morphometry
Divya Rani M N1, Aparna Narasimha2, Harendra Kumar Ml3
1Resident, Department of Pathology, Bangalore Medical College and Research Institute , Bangalore, Karnataka, India .
Background:
Cervical cancer is the second most common cancer occurring among women worldwide, with almost half a million new cases each year. Normal cells gradually transform to form cancer cells through several stages. So, the changes occurring during the transformational stages need to be assessed.
Aim:
Our aim was to study various nuclear parameters useful in evaluating pre-malignant and malignant cervico-vaginal pap smears.
Materials And Methods:
Bethesda System was used to categorize cervical pap smears into premalignant and malignant lesions. Nuclear parameters were calculated using J 1.44C morphometric software. Several nuclear size parameters were analysed.
Results:
The nuclear area, perimeter, diameter were found to be statistically significant (p<0.05) parameters in differentiating premalignant from malignant cervical smears.
Conclusion:
Nuclear morphometry was thus a useful objective tool in differentiating premalignant from malignant cervical smears.
