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Updated: Apr 18, 2026
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
Effect of atorvastatin on memory in albino mice
Rinku Rani Biswas1, Das M C2, Srinivasa Rao A S R3
1Senior Resident, Department of Pharmacology, Siddhartha Medical College , Vijayawada, Krishna Dt., Andhra Pradesh, India .
Objective:
The aim and objective of the present study was to evaluate the effect of atorvastatin on learning and memory in albino mice.
Materials And Methods:
Thirty Swiss albino mice were divided into 5groups (n=6). In group2, group4 and group5 hyperlipidemia was induced by high fat diet (HFD) orally for 28days. Atrorvastatin was given to group3, group4 and group5 orally for 14 d. Learning and memory was evaluated with Hebb Williams's maze, Elevated plus maze, Y maze and Step through latency. Continuous data were analyzed by one way ANOVA followed by Scheffe multiple range test, discrete data were analyzed by Kruskal - Wallis test. The level of significance was 5% (p ≤ 0.05).
Result And Conclusion:
HFD treatment had shown significant increase in body weight, significant impairment in learning and memory (p < 0.05). Only atorvastatin treated group had shown better learning and memory in comparison to HFD group. Atorvastatin 10mg/kg and 20 mg/kg had reversed the HFD induced impairment of learning and memory but there was no significant difference between the doses (p > 0.05).
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