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Glomerular disease in 2014: advances in basic science and translational medicine
Fernando C Fervenza1, Sanjeev Sethi2
1Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA.
Nature Reviews. Nephrology
|January 14, 2015
Summary
Advances in glomerular disease in 2014 included identifying thrombospondin type-1 domain-containing protein 7A in membranous nephropathy and confirming rituximab efficacy for nephrotic syndrome and vasculitis.
Area of Science:
- Nephrology and immunology.
- Pathogenesis and treatment of kidney diseases.
Background:
- Glomerular diseases encompass a range of kidney disorders affecting the glomeruli.
- Understanding disease mechanisms and therapeutic strategies is crucial for patient outcomes.
Purpose of the Study:
- To highlight key advancements in glomerular disease knowledge and therapy during 2014.
- To identify novel antigenic targets and assess therapeutic efficacy in specific nephropathies.
Main Methods:
- Review of key studies published in 2014.
- Identification of thrombospondin type-1 domain-containing protein 7A as a target in primary membranous nephropathy.
- Evaluation of rituximab's efficacy in specific patient cohorts.
Main Results:
- Thrombospondin type-1 domain-containing protein 7A was identified as an antigenic target in primary membranous nephropathy.
- Rituximab demonstrated efficacy as maintenance therapy for relapsing or steroid-dependent nephrotic syndrome.
- Rituximab also showed efficacy in antineutrophil cytoplasmic antibody-associated vasculitis.
Conclusions:
- Significant progress was made in understanding glomerular disease pathogenesis in 2014.
- Novel therapeutic targets and effective treatment strategies, including rituximab, were confirmed for key glomerular conditions.
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