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Updated: Apr 18, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
Chronic thromboembolic pulmonary hypertension.
Karen M Olsson1, Bernhard Meyer, Jan Hinrichs
1Department of Respiratory Medicine, German Center for Lung Research, Hannover Medical School, Institute of Diagnostic and Interventional Radiology, German Center for Lung Research, Hannover Medical School, Department of Cardiothoracic, Vascular and Transplantation Surgery, German Center for Lung Research, Hannover Medical School.
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by unresolved pulmonary blood clots. Effective treatments are available, making timely diagnosis and referral crucial for improved patient outcomes.
Area of Science:
- Cardiology
- Pulmonology
- Vascular Medicine
Background:
- Chronic thromboembolic pulmonary hypertension (CTEPH) arises from incomplete resolution of pulmonary artery clots.
- Untreated CTEPH significantly reduces life expectancy.
- Advances in treatment have improved outcomes for CTEPH patients.
Purpose of the Study:
- To review the diagnostic and treatment landscape for CTEPH.
- To highlight the importance of specialized care for CTEPH patients.
Main Methods:
- A selective literature search of PubMed was conducted.
- Articles published between 1980 and 2014 were included.
Main Results:
- Perfusion scintigraphy is highly effective for excluding CTEPH.
- Right-heart catheterization and pulmonary angiography confirm diagnosis.
- Pulmonary endarterectomy (PEA) cures approximately 70% of patients; perioperative mortality is 2-4%.
- Riociguat and pulmonary balloon angioplasty offer treatment options for inoperable patients.
Conclusions:
- Early diagnosis and referral to specialized centers are essential for CTEPH management.
- Current treatment options address most forms of CTEPH, improving prognosis.
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