Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

1.0K
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
1.0K
Psychosurgery01:30

Psychosurgery

2.4K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
2.4K
General Anesthesia: Overview01:24

General Anesthesia: Overview

1.2K
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
1.2K
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

1.1K
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementing Project Optimus in Oncology Dosage Optimization: Where are We Now?

Therapeutic innovation & regulatory science·2026
Same author

ABO-Incompatible Platelet Transfusions and Mortality Risk in Patients With Intracranial Hemorrhage.

Neurosurgery·2026
Same author

Safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy from a first-in-human study of volrustomig, a novel PD-1/CTLA-4 bispecific antibody.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Elevated glioma-related cortical glutamate <i>in vivo</i> is associated with <i>ex vivo</i> interictal discharges in human brain slices.

Brain communications·2025
Same author

Rheumatoid arthritis-associated interstitial lung disease: an overview.

QJM : monthly journal of the Association of Physicians·2025
Same author

Diffuse Alveolar Hemorrhage.

Seminars in respiratory and critical care medicine·2025

Related Experiment Video

Updated: Apr 18, 2026

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

12.0K

Side errors in neurosurgery and human factors training.

Patrick Mitchell1, Trevor Dale

  • 1Department of Neurosurgery, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK, patrick.mitchell@ncl.ac.uk.

Acta Neurochirurgica
|January 15, 2015
PubMed
Summary

Implementing systematic checking and human factors training significantly reduced side errors in neurosurgery. This intervention extended the mean time between errors from 2 months to 82 error-free months, enhancing patient safety.

More Related Videos

Simulator Training for Endovascular Neurosurgery
08:08

Simulator Training for Endovascular Neurosurgery

Published on: May 6, 2020

4.3K
Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model
08:11

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

12.1K

Related Experiment Videos

Last Updated: Apr 18, 2026

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

12.0K
Simulator Training for Endovascular Neurosurgery
08:08

Simulator Training for Endovascular Neurosurgery

Published on: May 6, 2020

4.3K
Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model
08:11

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

12.1K

Area of Science:

  • Neurosurgery
  • Patient Safety
  • Human Factors Engineering

Background:

  • Previous reports documented side errors in UK cranial neurosurgery before 2006.
  • A cluster of six cranial and spinal side errors in Newcastle upon Tyne in 2006 prompted further investigation.
  • The study aimed to investigate and resolve issues contributing to neurosurgical errors.

Purpose of the Study:

  • To evaluate the effectiveness of a human factors training program in reducing side errors in neurosurgery.
  • To assess the impact of systematic checking and briefing procedures on error rates.
  • To improve patient safety within neurosurgical departments.

Main Methods:

  • A human factors training program was implemented for all 125 neurosurgical theatre staff members.
  • Professional observation and coaching were conducted over fifteen days within the theatre suite.
  • Time between side errors was meticulously recorded to measure intervention effectiveness.

Main Results:

  • A standardized side checking system was universally adopted.
  • Pre-list briefing meetings became widely used, though universal adoption took years.
  • Mean time between errors increased from 2 months pre-intervention to 82 error-free months post-intervention.

Conclusions:

  • Systematic checking and education are effective in reducing neurosurgical side errors.
  • Human factors interventions, particularly education, can lower error rates significantly.
  • The study highlights the importance of a combined approach to enhance neurosurgical safety.