Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

3
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
3
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

4
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
4
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.2K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.2K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.5K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.5K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.6K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychiatry and the unknown future: the period of hope.

Frontiers in psychiatry·2026
Same author

Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2026 - Pharmacokinetic, pharmacogenetic and clinical aspects.

Pharmacopsychiatry·2026
Same author

Heatwave-related variations in psychiatric consultations and admissions: a time-series analysis.

Frontiers in psychiatry·2026
Same author

Socioeconomic status and perception of well-being and mental health support: a three-year COVID-19 study in children with psychopathology and their parents.

Pediatric research·2026
Same author

Lockdown COVID‑19: a stress test revealing more about the mental health system than psychopathology-A comparative analysis between Austria, Germany, and Italy.

Frontiers in public health·2026
Same author

[Current perspectives in electroconvulsive therapy].

Der Nervenarzt·2026

Related Experiment Video

Updated: Apr 18, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.7K

[Parkinson's disease and psychoses].

Jacopo Vittoriano Bizzarri1, Giancarlo Giupponi, Ignazio Maniscalco

  • 1LKH S. Maurizio, Boehlerstr. Nr. 5, 39100, Bozen, Italien.

Neuropsychiatrie : Klinik, Diagnostik, Therapie Und Rehabilitation : Organ Der Gesellschaft Osterreichischer Nervenarzte Und Psychiater
|January 15, 2015
PubMed
Summary

Parkinson's disease psychosis (PDP) affects 20-40% of patients, causing hallucinations and delusions. Treatment involves reducing anti-Parkinson's medications and using second-generation antipsychotics like clozapine.

More Related Videos

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
08:38

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

76.3K

Related Experiment Videos

Last Updated: Apr 18, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.7K
Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
08:38

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

76.3K

Area of Science:

  • Neurology
  • Psychiatry

Context:

  • Parkinson's disease (PD) psychosis (PDP) is a common and debilitating non-motor symptom.
  • PDP significantly increases disability and worsens quality of life in PD patients.

Purpose:

  • To review the clinical features, pathogenesis hypotheses, and current treatment strategies for Parkinson's disease psychosis.
  • To provide an overview of the prevalence and impact of psychotic symptoms in PD.

Summary:

  • PDP affects 20-40% of Parkinson's disease patients, with complex visual hallucinations being the most frequent symptom.
  • Pathophysiology involves dopaminergic medications, neurotransmitter imbalances, neuroanatomy, visuospatial deficits, and genetics.
  • Treatment prioritizes reducing anti-PD medications, with second-generation antipsychotics, particularly clozapine, as the preferred pharmacological approach.

Impact:

  • Highlights the need for effective management strategies for PDP to improve patient outcomes.
  • Informs clinical practice regarding the diagnosis and treatment of psychosis in Parkinson's disease.
  • Underscores the significant burden of PDP on patients and the healthcare system.