Related Experiment Video
Updated: Apr 18, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
Published on: April 23, 2014
The effect of raloxifene on symptoms and cognitive functioning in a postmenopausal schizophrenia patient: a case
Elena Huerta-Ramos1,2,3, Susana Ochoa4,5, Mercedes Roca4,5
1Parc Sanitari Sant Joan de Déu, C/Antoni Pujadas, 42, Sant Boi de Llobregat, 08830, Barcelona, Spain. mehuerta@pssjd.org.
Abstract:
We report on a 61-year-old postmenopausal female with schizophrenia included in a raloxifene vs. placebo clinical trial and monitored during a 12-month period including a 3-month withdrawal period (6-9 months) without treatment. The patient was treated with raloxifene 60 mg/day adjuvant to antipsychotic medication for 6 months, medication was then withdrawn for 3 months and was reintroduced due to a worsening of symptoms. We assessed the patient with PANSS and other neuropsychological tests. The patient improved in psychopathology and cognitive level in some aspects related to executive functions. During 3 months without the drug, the patient's condition deteriorated. When the drug was reintroduced, improvements were again observed. Raloxifene may be useful as an adjuvant treatment for psychopathological symptoms and some cognitive aspects in women with chronic schizophrenia.
Related Concept Videos
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Drug Therapy
Antianxiety Medications
Schizophrenia

