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Updated: Apr 18, 2026

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis
F De Vadder1, F Plessier, A Gautier-Stein
1Institut de la Santé et de la Recherche Médicale, U855, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France.
Abstract:
Intestinal gluconeogenesis (IGN) promotes metabolic benefits through activation of a gut-brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (i) vasoactive intestinal peptide (VIP) signaling through VPAC1 receptor activates the intestinal glucose-6-phosphatase gene in vivo, (ii) the activation of IGN by propionate is counteracted by VPAC1 antagonism, and (iii) VIP-positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes.
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