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Distribution and antimicrobial resistance of enteric pathogens in Chinese paediatric diarrhoea: a multicentre

H Zhang1, F Pan1, X Zhao2

  • 1Department of Clinical Laboratory,Shanghai Children's Hospital, Shanghai Jiaotong University,Shanghai,China.

Epidemiology and Infection
|January 15, 2015
PubMed

Insights

This study identified Salmonella and diarrhoeagenic Escherichia coli as leading enteric pathogens in Chinese children. Multidrug resistance was significant in Shigella and Salmonella strains.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Enteric pathogens causing diarrhea severely impact children's health globally.
  • Understanding regional prevalence and antimicrobial resistance patterns is crucial for effective treatment and public health strategies.

Purpose of the Study:

  • To analyze the prevalence and antimicrobial susceptibility of enteric pathogens in children across different regions of China.
  • To identify key pathogens, their distribution, and resistance trends from 2008 to 2013.

Main Methods:

  • Retrospective analysis of 1577 enteric pathogens isolated from pediatric inpatients and outpatients in six Chinese hospitals.
  • Data collected from Northern, Northeastern, Eastern, Southern, and Central China between 2008 and 2013.
  • Antimicrobial susceptibility testing was performed on isolated pathogens.

Main Results:

  • Salmonella (36.0%) and diarrhoeagenic Escherichia coli (23.7%) were the most frequent enteric pathogens.
  • Pathogen prevalence varied regionally; Salmonella was most common in Shanghai and Hainan, while diarrhoeagenic E. coli predominated in Inner Mongolia, Jiangsu, and Hubei.
  • Shigella exhibited higher resistance to ampicillin, ceftriaxone, and sulfamethoxazole compared to Salmonella. Multidrug resistance was prevalent in both, particularly in Shigella flexneri.

Conclusions:

  • Salmonella and diarrhoeagenic E. coli are major enteric pathogens in Chinese children, with distinct regional distributions.
  • Significant antimicrobial resistance, including multidrug resistance, is a concern in Shigella and Salmonella, necessitating careful antibiotic selection.
  • Findings highlight the need for ongoing surveillance and tailored interventions to combat pediatric enteric infections in China.

Keywords:
Antibiotic resistanceSalmonellaShigellabacteriologydiarrhoea

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