Related Experiment Video
Updated: Aug 25, 2026

17:14
Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
Published on: December 10, 2012
Chromosome analysis of in situ breast cancer
K V Nielsen1, M Blichert-Toft, J Andersen
1Department of Pathology, Odense University Hospital, Denmark.
Acta Oncologica (Stockholm, Sweden)
|January 1, 1989
Abstract:
Eleven ductal carcinoma in situ (DCIS), 5 DCIS with microinvasion and 4 benign lesions have been investigated cytogenetically. Twelve of the 20 breast tumors (60%) had sufficient mitotic activity for chromosome analysis. All ductal carcinoma in situ had abnormal karyotypes, and clonal marker chromosomes could be identified in all tumors analyzed. None were cytogenetically normal. All but one of the 12 DCIS showed genetic heterogeneity. Tumor progression seems to be associated with loss of chromosomes.

