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Updated: Apr 18, 2026

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

Diffuse Interstitial Pulmonary Infiltrates in Malignant Melanoma.

Jens Bräunlich¹, Hans-Jürgen Seyfarth², Armin Frille²

¹Department of Pulmonary Medicine, University of Leipzig, Leipzig, Germany. highflow@web.de.

Respiratory Care

|January 15, 2015

Summary

A rare sarcoidosis-like reaction occurred in a melanoma patient undergoing long-term interferon alpha-2 therapy. This case highlights a potential adverse effect of this melanoma treatment.

Keywords:

drug reactions interferon alpha-2 melanoma rare lung diseases sarcoidosis-like reactions

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Last Updated: Apr 18, 2026

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Published on: May 24, 2016

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Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

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Published on: January 31, 2025

Area of Science:

Pulmonology
Oncology
Dermatology

Background:

Melanoma treatment often involves immunotherapy, such as interferon alpha.
Sarcoidosis-like reactions are uncommon drug-induced side effects.

Observation:

A 25-year-old man with a history of malignant melanoma presented with diffuse interstitial pulmonary infiltrates.
Computed tomography revealed enlarged mediastinal lymph nodes.

Findings:

The patient had received 18 months of interferon alpha-2 therapy.
Histological analysis of a transbronchial biopsy confirmed a sarcoidosis-like reaction.

Implications:

Interferon alpha-2 therapy may induce sarcoidosis-like reactions in melanoma patients.
Clinicians should consider this potential adverse effect in patients with similar presentations.
Further research is needed to understand the mechanisms of this reaction.