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Maraviroc Failed to Control Progressive Multifocal Leukoencephalopathy-Associated IRIS in a Patient with Advanced HIV
Mónica Rodríguez1, Fernando Antonio Silva-Sánchez1, César Luna-Rivero2
1Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Colonia Sección XVI, 14080 México, DF, Mexico.
Case Reports in Medicine
|January 15, 2015
Summary
Maraviroc showed limited efficacy for progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-associated IRIS) in an advanced HIV patient. Further research is needed to determine its therapeutic role in PML-associated IRIS.
Area of Science:
- Neuroimmunology
- Infectious Diseases
- HIV Medicine
Background:
- Progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-associated IRIS) lacks effective treatments.
- Maraviroc has been considered a potential therapeutic option for PML-associated IRIS.
Purpose of the Study:
- To report a case of PML-associated IRIS in an advanced HIV patient treated with maraviroc.
- To evaluate the efficacy of maraviroc in managing PML-associated IRIS.
Main Methods:
- Case report of an advanced HIV patient.
- Treatment with maraviroc in addition to suppressive antiretroviral therapy (ART).
- Clinical and neurological outcome assessment.
Main Results:
- The patient developed PML-associated IRIS and had a fatal outcome.
- Despite the addition of maraviroc to ART, neurological deterioration occurred.
Conclusions:
- Maraviroc may not be effective in all cases of PML-associated IRIS.
- Further studies are required to define the role of maraviroc in PML-associated IRIS.
- Identifying patient subgroups who may benefit from maraviroc is crucial.
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