Related Experiment Videos
Export of proteins across membranes: the helix reversion hypothesis
U P Shinde1, T N Guru Row, Y R Mawal
1Division of Chemical Engineering, National Chemical Laboratory, Pune, India.
Bioscience Reports
|December 1, 1989
Abstract:
A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.