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Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation
Hui Sun1, Huiyu Wang, Aihua Zhang
1National TCM Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine , Harbin, China .
Omics : a Journal of Integrative Biology
|January 15, 2015
Summary
Berberine treatment partially reversed metabolic disturbances in a rat model of nonbacterial prostatitis (NBP). This study identified 14 potential biomarkers and 5 pathways involved in berberine
Area of Science:
- Metabolomics
- Pharmacology
- Biochemistry
Background:
- Metabolomics is crucial for biomarker discovery and pathway analysis.
- Berberine possesses anti-inflammatory, antioxidant, and anticancer properties.
- Mechanisms of berberine in treating nonbacterial prostatitis (NBP) are not fully understood.
Purpose of the Study:
- To investigate the therapeutic mechanisms of berberine in a rat model of capsaicin-induced NBP.
- To identify novel urinary biomarkers and perturbed metabolic pathways affected by berberine treatment using untargeted metabolomics.
Main Methods:
- Utilized ultra-performance liquid chromatography-quadrupole time-of-flight-high definition mass spectrometry (UPLC-Q-TOF-HDMS) for untargeted metabolomics.
- Analyzed urine samples from a rat model of capsaicin-induced NBP before and after berberine treatment.
- Employed principal component analysis (PCA) to assess metabolic profile changes.
Main Results:
- Berberine treatment partially reversed NBP-induced metabolic profile disturbances, as indicated by PCA.
- Identified 14 potential biomarkers and 5 acutely perturbed metabolic pathways involved in NBP treatment.
- Observed regulation of 12 potential biomarkers after berberine administration, suggesting metabolic pathway involvement.
Conclusions:
- Berberine exerts protective effects in NBP, partly by reversing NBP-induced metabolic disturbances.
- The therapeutic action of berberine in NBP involves the regulation of metabolic pathways.
- Identified biomarkers and pathways provide insights into berberine's efficacy for NBP.