Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

11.1K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
11.1K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

562
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
562
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

650
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
650
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

715
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
715
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

465
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
465
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

641
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
641

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MeshGrow: Integrated framework for simulation-ready cardiac and vascular mesh construction from medical imaging.

JRSM cardiovascular disease·2026
Same author

Data-driven system identification in cancer systems biology: A multiscale modeling approach to melanoma.

Computer methods and programs in biomedicine·2026
Same author

Automated Centerline Extraction From Meshed Vascular Models.

International journal for numerical methods in biomedical engineering·2026
Same author

Therapeutic embolic agents for targeted drug delivery in transcatheter therapies: a review.

Chemical communications (Cambridge, England)·2026
Same author

A dual-lumen microcatheter for minimizing particle reflux during embolization: Proof-of-concept with multiphysics simulations.

Computers in biology and medicine·2026
Same author

Multiscale Coronary Arterial Network Generation and Hemodynamics Using Patient-Specific Fractional Myocardial Blood Volume.

Bioengineering (Basel, Switzerland)·2025

Related Experiment Video

Updated: Apr 18, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

7.0K

Mechanical platelet activation potential in abdominal aortic aneurysms.

Kirk B Hansen, Amirhossein Arzani, Shawn C Shadden

    Journal of Biomechanical Engineering
    |January 15, 2015
    PubMed
    Summary

    Biomechanical platelet activation is unlikely to drive intraluminal thrombus (ILT) formation in abdominal aortic aneurysms (AAA). Computational fluid dynamic (CFD) models suggest stress-induced platelet activation potential (AP) is minimal under typical conditions.

    More Related Videos

    A New Murine Model of Endovascular Aortic Aneurysm Repair
    08:51

    A New Murine Model of Endovascular Aortic Aneurysm Repair

    Published on: July 7, 2013

    14.9K
    Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms
    07:42

    Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

    Published on: July 26, 2024

    3.1K

    Related Experiment Videos

    Last Updated: Apr 18, 2026

    Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
    09:32

    Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

    Published on: February 23, 2020

    7.0K
    A New Murine Model of Endovascular Aortic Aneurysm Repair
    08:51

    A New Murine Model of Endovascular Aortic Aneurysm Repair

    Published on: July 7, 2013

    14.9K
    Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms
    07:42

    Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

    Published on: July 26, 2024

    3.1K

    Area of Science:

    • Cardiovascular Science
    • Biomedical Engineering
    • Hemodynamics

    Background:

    • Intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAA) is linked to aneurysm progression and rupture risk.
    • The precise mechanisms driving ILT formation, particularly biomechanical platelet activation, remain unclear.
    • Previous studies focused on wall shear stress (WSS) but did not quantify platelet activation potential (AP).

    Purpose of the Study:

    • To computationally analyze stress-induced platelet activation potential (AP) within patient-specific abdominal aortic aneurysms (AAA).
    • To compare AP under rest and exercise hemodynamic conditions using different modeling approaches.
    • To investigate the role of biomechanical factors in ILT development.

    Main Methods:

    • Patient-specific computational fluid dynamic (CFD) models were employed.
    • Lagrangian particle-based and Eulerian continuum-based approaches were used to simulate platelet activation.
    • Analysis was performed for both rest and exercise flow conditions within the AAA.

    Main Results:

    • Biomechanical platelet activation was found unlikely to be a significant factor in ILT formation for the simulated conditions.
    • No consistent trend in AP was observed between rest and exercise states.
    • The Lagrangian method yielded higher peak AP values, but these were below physiologically significant levels.

    Conclusions:

    • The study suggests that biomechanical platelet activation plays a minimal role in intraluminal thrombus formation in abdominal aortic aneurysms.
    • Hemodynamic conditions alone, under typical rest and exercise scenarios, may not be sufficient to trigger significant platelet activation leading to ILT.
    • Further research may explore other contributing factors or more extreme physiological conditions influencing ILT development.