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Theranostic mercury: (197(m))Hg with high specific activity for imaging and therapy
Martin Walther1, Stephan Preusche1, Stig Bartel2
1Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
Abstract:
The no carrier added (NCA) radionuclide (197(m))Hg is accessible through proton induced nuclear reactions on gold. The decay properties of both simultaneous produced nuclear isomers (197m)Hg and (197)Hg like convenient half life, low energy gamma radiations for imaging, Auger and conversion electrons for therapy are combined with unique chemical and physical properties of mercury and its compounds. Gold as a monoisotopic element has a natural abundance of 100% (197)Au superseding expensive enrichment for the target material. Additionally, the high thermal conductivity of gold enables high beam current irradiations. For separation of target material a liquid-liquid extraction method was applied.
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