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Within-visit blood pressure variability is associated with prediabetes and diabetes

Rieko Okada1, Yoshinari Yasuda2, Kazuyo Tsushita3

  • 1Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Scientific Reports
|January 16, 2015
PubMed

Insights

Increased blood pressure variability (BPV) within a single visit is linked to higher rates of prediabetes and diabetes. This finding suggests BPV may help identify individuals at risk for glycemic control issues.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Cardiovascular disease (CVD) risk factors are a major public health concern.
  • Blood pressure variability (BPV) is an emerging marker for cardiovascular risk.
  • The relationship between within-visit BPV and glycemic status is not well understood.

Purpose of the Study:

  • To investigate the association between within-visit systolic blood pressure variability (ΔSBP) and risk factors for cardiovascular disease (CVD).
  • To determine if increased BPV is associated with prediabetes and diabetes in a large general population.

Main Methods:

  • A cross-sectional study of 17,795 adults aged 40-74 years in Aichi Prefecture, Japan.
  • Two blood pressure measurements were taken during a single health check-up visit.
  • Subjects were categorized into low (≤ 10 mmHg), moderate (11-20 mmHg), and high (> 20 mmHg) ΔSBP groups.
  • Glycemic status was assessed using glycosylated hemoglobin A1c (HbA1c) levels, categorizing participants into non-prediabetes, prediabetes, and diabetes.

Main Results:

  • Higher within-visit BPV was significantly associated with a greater prevalence of prediabetes and diabetes.
  • After adjusting for age, sex, and mean systolic blood pressure (SBP), the odds ratios for prediabetes and diabetes were 1.16 (95% CI: 1.01-1.33) and 1.33 (95% CI: 1.06-1.66), respectively, in the high-BPV group compared to the low-BPV group.
  • No significant associations were found between high-BPV and other CVD risk factors after adjustment.

Conclusions:

  • Increased within-visit blood pressure variability is independently associated with the prevalence of prediabetes and diabetes in a large general population.
  • Assessing within-visit BPV during a single health check-up may serve as a valuable tool for identifying individuals at higher risk of impaired glycemic control.
  • These findings highlight the importance of considering blood pressure fluctuations beyond average levels for comprehensive cardiovascular risk assessment.

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