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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Apr 18, 2026

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

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Functional brain imaging in respiratory medicine.

Kyle Pattinson

    Thorax
    |January 16, 2015
    PubMed
    Summary

    Brain imaging using functional MRI (fMRI) may explain why some patients with lung disease experience severe symptoms despite mild pathology. This technology offers new insights into conditions like breathlessness, chronic cough, and asthma.

    Area of Science:

    • Neuroscience and Respiratory Medicine
    • Clinical Research Applications of Functional MRI

    Background:

    • A significant disconnect exists between reported symptoms and objective disease severity in respiratory conditions such as chronic lung disease, chronic cough, and asthma.
    • This symptom-pathology discordance, exemplified by 'over perceivers' and 'under perceivers' in asthma, suggests underlying aberrant brain mechanisms.
    • Traditional pulmonary function tests often fail to correlate well with patient-reported symptoms like breathlessness.

    Purpose of the Study:

    • To explore the potential of functional MRI (fMRI) as a tool to investigate the neural basis of symptom perception in respiratory diseases.
    • To elucidate the role of aberrant brain mechanisms in the discordance between clinical symptoms and disease markers.
    • To review current fMRI findings related to breathlessness, cough, and asthma.
    Keywords:
    Perception of Asthma/Breathlessness

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    Main Methods:

    • Explanation of the principles and advancements in functional MRI (fMRI) technology for measuring brain activity non-invasively.
    • Review of existing literature and research utilizing fMRI to study neural responses in patients with respiratory conditions.
    • Focus on fMRI's application in understanding symptom perception in breathlessness, chronic cough, and asthma.

    Main Results:

    • Functional MRI has emerged as a viable and advanced technique for clinical research into brain function.
    • Preliminary fMRI studies provide insights into how the brain processes symptoms in respiratory diseases, potentially explaining symptom-pathology mismatches.
    • The technology is capable of revealing neural correlates of subjective experiences like breathlessness and cough.

    Conclusions:

    • Functional MRI offers a promising non-invasive approach to understanding the neurobiological underpinnings of symptom perception in respiratory diseases.
    • Further research using fMRI could clarify the mechanisms behind symptom-pathology discordance in conditions like asthma, chronic cough, and breathlessness.
    • This technology holds potential for developing more targeted and effective therapeutic strategies by addressing central nervous system contributions to respiratory symptoms.