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[Determination of potential carcinogenicity of nickel-containing dust using a micronuclear test]
Gigiena Truda I Professional'Nye Zabolevaniia
|January 1, 1989
Abstract:
Mutagenic activity of 3 samples of nickel-containing dusts was experimentally studied in white random-bred rats. Quantity of micronuclei in polychromatophilic erythrocytes of bone marrow smear depended on nickel dust content. Micronuclear test could be used as a rapid method for the determination of potential carcinogenic activity of polymetallic nickel-containing dusts and also as a factor confirming oncologic hazard of chemical substances combined with epidemiologic studies and chronic experiment on animals.
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