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Updated: Apr 18, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Antisense Modulation of RNA Processing as a Therapeutic Approach in Cancer Therapy

Lee Spraggon1, Luca Cartegni1

  • 1Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, USA.

Drug Discovery Today. Therapeutic Strategies
|January 16, 2015
PubMed

Insights

Next-generation antisense technologies offer new treatments for genetic diseases and cancer. These advanced methods reprogram gene expression to combat drug resistance and target previously undruggable conditions.

Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Next-generation antisense technologies are gaining traction for treating genetic disorders.
  • These strategies are also being explored for novel cancer therapies.

Purpose of the Study:

  • To investigate the potential of antisense technologies in reprogramming gene expression for therapeutic benefit.
  • To explore the application of these technologies in overcoming challenges in cancer treatment, such as drug resistance and targeting previously intractable targets.

Main Methods:

  • Interfering with alternative splicing processes.
  • Modulating polyadenylation of messenger RNA.
  • Developing functional antagonists for endogenous oncogenic products.

Main Results:

  • Antisense strategies show promise in reprogramming oncogene expression.
  • These approaches can potentially yield functional antagonists.
  • The methods address acquired drug resistance and previously undruggable targets in cancer.

Conclusions:

  • Next-generation antisense technologies represent a powerful therapeutic approach for genetic diseases and cancer.
  • Reprogramming gene expression via splicing or polyadenylation interference offers a novel strategy for challenging medical conditions.

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