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Ocular drug delivery systems: An overview
Ashaben Patel1, Kishore Cholkar1, Vibhuti Agrahari1
1Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri-64108, United States.
World Journal of Pharmacology
|January 16, 2015
Summary
Ocular drug delivery faces challenges with eye drops. Novel formulations and devices improve drug targeting and retention, enhancing treatment for eye diseases.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Drug Delivery Systems
Background:
- Ocular drug delivery is a significant challenge for pharmacologists and formulation scientists.
- Conventional topical eye drops face barriers limiting drug efficacy and duration.
- Developing advanced formulations is crucial for effective ocular disease treatment.
Purpose of the Study:
- To review advancements in ocular drug delivery formulations and techniques.
- To summarize conventional and novel approaches for anterior and posterior ocular delivery.
- To provide an update on nanotechnology-based strategies and other delivery systems.
Main Methods:
- Review of existing literature on ocular drug delivery.
- Analysis of conventional formulations (solutions, suspensions, ointments).
- Exploration of novel nanoformulations, in situ gels, implants, contact lenses, and microneedles.
Main Results:
- Conventional formulations are enhanced with permeation and viscosity modifiers.
- Nanoformulations offer improved drug delivery for anterior and posterior segments.
- Novel devices and formulations show potential for sustained release and enhanced bioavailability.
Conclusions:
- Advanced ocular drug delivery systems are essential to overcome biological barriers.
- Novel formulations and devices offer improved safety, efficacy, and patient compliance.
- Continued research in nanotechnology and innovative delivery strategies is vital for ocular therapeutics.
Keywords:
Anatomy and physiologyContact lensCorneaDrug deliveryEmulsionsEyeFormulationsImplantsLiposomesNanomicellesOintmentsRetinaSuspensionsMore Related Videos
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