Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

252
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
252
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

250
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
250
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

211
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
211
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.2K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.2K
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

268
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
268
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

1.1K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small Vesicles Big Impact: Exosomes in the Landscape of Women's Health.

Pharmaceutical research·2026
Same author

Thermoresponsive hydrogels for controlled drug delivery to the back of the eye: a data-driven guide to formulation design.

Biomaterials science·2026
Same author

Rationally designed sodium thiosulfate-loaded solid lipid nanoparticles for inner ear delivery and prevention of medication-induced ototoxicity.

Journal of materials chemistry. B·2025
Same author

A multimodal approach to smart and sustained drug delivery for corneal wound management: the GelPol nanoformulation.

Nanomedicine (London, England)·2025
Same author

Corneal Treatment, Repair, and Regeneration: Exosomes at Rescue.

Pharmaceutics·2024
Same author

Crosslinked-hybrid nanoparticle embedded in thermogel for sustained co-delivery to inner ear.

Journal of nanobiotechnology·2024

Related Experiment Video

Updated: Apr 18, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

1.2K

Ocular drug delivery systems: An overview.

Ashaben Patel1, Kishore Cholkar1, Vibhuti Agrahari1

  • 1Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri-64108, United States.

World Journal of Pharmacology
|January 16, 2015
PubMed
Summary

Ocular drug delivery faces challenges with eye drops. Novel formulations and devices improve drug targeting and retention, enhancing treatment for eye diseases.

Keywords:
Anatomy and physiologyContact lensCorneaDrug deliveryEmulsionsEyeFormulationsImplantsLiposomesNanomicellesOintmentsRetinaSuspensions

More Related Videos

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.9K
Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

2.0K

Related Experiment Videos

Last Updated: Apr 18, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

1.2K
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.9K
Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

2.0K

Area of Science:

  • Ophthalmology
  • Pharmaceutics
  • Drug Delivery Systems

Background:

  • Ocular drug delivery is a significant challenge for pharmacologists and formulation scientists.
  • Conventional topical eye drops face barriers limiting drug efficacy and duration.
  • Developing advanced formulations is crucial for effective ocular disease treatment.

Purpose of the Study:

  • To review advancements in ocular drug delivery formulations and techniques.
  • To summarize conventional and novel approaches for anterior and posterior ocular delivery.
  • To provide an update on nanotechnology-based strategies and other delivery systems.

Main Methods:

  • Review of existing literature on ocular drug delivery.
  • Analysis of conventional formulations (solutions, suspensions, ointments).
  • Exploration of novel nanoformulations, in situ gels, implants, contact lenses, and microneedles.

Main Results:

  • Conventional formulations are enhanced with permeation and viscosity modifiers.
  • Nanoformulations offer improved drug delivery for anterior and posterior segments.
  • Novel devices and formulations show potential for sustained release and enhanced bioavailability.

Conclusions:

  • Advanced ocular drug delivery systems are essential to overcome biological barriers.
  • Novel formulations and devices offer improved safety, efficacy, and patient compliance.
  • Continued research in nanotechnology and innovative delivery strategies is vital for ocular therapeutics.