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Updated: Apr 18, 2026
Murine Renal Transplantation Procedure
Published on: July 10, 2009
Relationship of maternal creatinine to first neonatal creatinine in infants <30 weeks gestation
A S Weintraub1, A Carey2, J Connors2
11] Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, Mount Sinai Medical Center, The Icahn School of Medicine at Mount Sinai, New York, NY, USA [2] The Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Objective:
To examine the relationship between maternal and neonatal creatinine (Cr) in preterm infants in the context of antenatal and intrapartum maternal and neonatal factors.
Study Design:
In this 5½-year, single-center, retrospective study, paired maternal and neonatal Cr were compared by t-test. Linear regression for correlated outcomes employing generalized estimating equations was used to examine neonatal Cr as a function of antenatal maternal Cr and potential confounders.
Result:
A total of 157 neonates of 124 mothers met study criteria. Neonatal Cr values in the first 24 h of life were significantly higher than antenatal maternal values. Linear regression modeling showed that maternal Cr, neonatal lactate, hypoxic-ischemic villous changes on placental pathology and multiple gestation were each significant determinants of the first neonatal Cr.
Conclusion:
No neonatal Cr was less than its paired maternal value. Maternal Cr, neonatal lactate, hypoxic-ischemic villous changes in the placenta and multiple gestation were each significantly associated with neonatal Cr.
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