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Dementia is associated with chronic rhinosinusitis: a population-based case-controlled study.
Shiu-Dong Chung1, Shih-Han Hung, Herng-Ching Lin
1Sleep Research Center, Taipei Medical University, Taipei, Taiwan.
American Journal of Rhinology & Allergy
|January 16, 2015
Summary
Individuals with dementia were more likely to have a history of chronic rhinosinusitis (CRS). This population-based study suggests a potential link between CRS and dementia risk.
Area of Science:
- Neurology
- Otolaryngology
- Epidemiology
Background:
- Cardiovascular diseases are linked to both chronic rhinosinusitis (CRS) and dementia.
- The association between dementia and prior CRS remains underexplored.
Purpose of the Study:
- To investigate the association between dementia and a history of chronic rhinosinusitis (CRS).
Main Methods:
- A population-based case-control study utilizing the Taiwan Longitudinal Health Insurance Database 2000.
- Included 8,768 dementia cases and 8,768 matched controls.
- Conditional logistic regression analyzed the association of dementia with previously diagnosed CRS.
Main Results:
- 5.0% of subjects had a prior CRS diagnosis.
- Prevalence of prior CRS was significantly higher in dementia cases (6.0%) versus controls (4.0%) (p < 0.001).
- Adjusted odds ratio (OR) for prior CRS in dementia subjects was 1.44 (95% CI, 1.25–1.66), with similar ORs for males (1.48) and females (1.41).
Conclusions:
- Subjects with dementia demonstrated a higher likelihood of having had prior CRS.
- Findings suggest a potential association between chronic rhinosinusitis and dementia.
