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Updated: Apr 18, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Pro-moieties of antimicrobial peptide prodrugs
1Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9, Ireland. eannaforde@rcsi.ie.
Abstract:
Antimicrobial peptides (AMPs) are a promising class of antimicrobial agents that have been garnering increasing attention as resistance renders many conventional antibiotics ineffective. Extensive research has resulted in a large library of highly-active AMPs. However, several issues serve as an impediment to their clinical development, not least the issue of host toxicity. An approach that may allow otherwise cytotoxic AMPs to be used is to deliver them as a prodrug, targeting antimicrobial activity and limiting toxic effects on the host. The varied library of AMPs is complemented by a selection of different possible pro-moieties, each with their own characteristics. This review deals with the different pro-moieties that have been used with AMPs and discusses the merits of each.
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