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Related Experiment Video

Updated: Apr 18, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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Paraneoplastic nerve hyperexcitability.

Jennifer A Liebenthal, Kourosh Rezania, Martin K Nicholas

    Neurological Research
    |January 17, 2015
    PubMed
    Summary

    Paraneoplastic nerve hyperexcitability syndromes, like Isaacs' and Morvan's, are neuroimmunologic conditions often linked to cancer. Management involves antiepileptic and immunomodulatory therapies.

    Area of Science:

    • Neurology
    • Immunology
    • Oncology

    Background:

    • Nerve hyperexcitability syndromes are rare neurological disorders.
    • These syndromes can be associated with underlying malignancies (paraneoplastic).

    Purpose of the Study:

    • To review paraneoplastic nerve hyperexcitability syndromes.
    • To detail Isaacs' syndrome and Morvan's syndrome, differentiating their clinical and neurological involvement.

    Main Methods:

    • Extensive literature review focusing on nerve hyperexcitability.
    • Analysis of studies on Isaacs' syndrome, Morvan's syndrome, and their paraneoplastic links.

    Main Results:

    • Detailed clinical and neurophysiologic manifestations of these syndromes are presented.
    Keywords:
    Isaacs’ syndrome,Morvan’s syndromeMyokymia,Nervous system,Paraneoplastic syndromes,

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  • Pathophysiology involves immune-mediated dysfunction of voltage-gated potassium channel (VGKC) complexes.
  • Distinction between peripheral (Isaacs') and central/peripheral (Morvan's) nervous system involvement is clarified.

    • Conclusions:

    • Nerve hyperexcitability syndromes form a spectrum of neuroimmunologic diseases.
    • A significant proportion of these syndromes have a paraneoplastic origin.