Related Experiment Video
Updated: Apr 18, 2026

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
Published on: December 27, 2024
Vitamin E and risk of age-related cataract: a meta-analysis
Yufei Zhang1, Wenjie Jiang1, Zhutian Xie1
1Department of Epidemiology and Health Statistics,Qingdao University Medical College,No. 38 Dengzhou Road,Qingdao 266021,People's Republic of China.
Objective:
We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC).
Design:
The fixed- or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model.
Setting:
Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions.
Subjects:
Studies involved samples of people of all ages.
Results:
Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95% CI 0·58, 0·92), 0·86 (95% CI 0·75, 0·99) and 0·77 (95% CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95% CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0·94; 95% CI 0·90, 0·97).
Conclusions:
The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.
Related Concept Videos
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Photoreceptors and Visual Pathways
Vitamins
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacodynamics in Geriatric Patients: Effects of Age
The Effect of Aging on Tissues

