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Updated: Apr 18, 2026

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
Published on: December 9, 2017
Defining the orphan functions of lysine acetyltransferases
David C Montgomery1, Alexander W Sorum, Jordan L Meier
1National Cancer Institute , Chemical Biology Laboratory, Frederick, Maryland 21702-1201, United States.
Abstract:
Long known for their role in histone acetylation, recent studies have demonstrated that lysine acetyltransferases also carry out distinct "orphan" functions. These activities impact a wide range of biological phenomena including metabolism, RNA modification, nuclear morphology, and mitochondrial function. Here, we review the discovery and characterization of orphan lysine acetyltransferase functions. In addition to highlighting the evidence and biological role for these functions in human disease, we discuss the part emerging chemical tools may play in investigating this versatile enzyme superfamily.
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