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Diseases of the Liver and Gallbladder01:26

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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[Liver diseases and pregnancy].

G Guettrot-Imbert1, A Plessier2, S Hillaire3

  • 1Service de médecine interne, hôpital Gabriel-Montpied, CHU de Clermont-Ferrand, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 1, France.

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Summary

Pregnant women can experience various liver diseases, some pregnancy-related and others coincidental. This review updates management strategies for optimal maternal and fetal outcomes in liver disease during pregnancy.

Keywords:
Atteintes hépatiquesGrossesseLiver disordersPregnancy

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Area of Science:

  • Hepatology
  • Obstetrics
  • Maternal-Fetal Medicine

Context:

  • Liver disease in pregnant women presents diverse etiologies, including pregnancy-specific conditions and those unrelated to gestation.
  • Manifestations like jaundice, pruritus, and abnormal liver tests signal potential liver disorders during pregnancy.
  • Pregnancy can exacerbate pre-existing liver conditions or increase susceptibility to new ones, such as viral hepatitis or gallstones.

Purpose:

  • To provide an updated review of liver diseases observed during pregnancy.
  • To outline management principles for various hepatic disorders in pregnant patients.
  • To minimize maternal and fetal complications and ensure favorable prognoses.

Summary:

  • Liver diseases in pregnancy encompass intrahepatic cholestasis, acute fatty liver, preeclampsia-induced injury, and coincidental conditions like viral hepatitis.
  • Pre-existing liver disease requires careful consideration due to feto-maternal transmission risks and potential decompensation.
  • Effective management strategies are crucial for improving maternal and fetal outcomes.

Impact:

  • Enhances clinical decision-making for managing liver disease in pregnant patients.
  • Aims to reduce the incidence of severe maternal and fetal complications.
  • Contributes to improved overall maternal and fetal health in obstetric hepatology.