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Updated: Apr 18, 2026

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
Published on: November 20, 2016
[Atypical genesis of anterior ischemic optic neuropathy]
R M Dutescu1, J P Klein, J Schroeter
1Augenklinik, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Deutschland, dutescumichael@googlemail.com.
Background:
This article presents a case of arteritic anterior ischemic optic neuropathy as a manifestation of granulomatosis with polyangiitis (GPA).
Case Report:
A 52-year-old woman suffered acute unilateral vision loss. Besides a unilateral papillary edema, serological investigations revealed elevated inflammation parameters with a positive (cytoplasmic) anti-neutrophil cytoplasmic autoantibodies (c-ANCA) titer. In addition to the occurrence of pulmonary nodules and cavitary lesions this is indicative for the diagnosis of GPA.
Results:
Treatment with cyclophosphamide and prednisolone led to a rapid regression of inflammation parameters but no visual improvement occurred.
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