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Interactions of the renin-angiotensin system in colorectal cancer and metastasis

W Kurtis Childers1

  • 1Department of Surgery, Pinnacle Health System, Harrisburg, PA, 17104, USA, wchilders@pinnaclehealth.org.

International Journal of Colorectal Disease
|January 17, 2015
PubMed

Insights

The renin-angiotensin system (RAS) plays a role in cardiovascular homeostasis and cancer. Inhibiting the angiotensin II type I receptor (AT1R) with ACE inhibitors may reduce solid tumor development and metastasis, particularly in colorectal cancer.

Area of Science:

  • Oncology
  • Cardiovascular Research
  • Pharmacology

Background:

  • The renin-angiotensin system (RAS) is crucial for cardiovascular homeostasis.
  • Angiotensin II (ANG II), a key RAS mediator, impacts solid tumor formation, angiogenesis, and metastasis.
  • RAS components are found in various malignant tissues.

Purpose of the Study:

  • To investigate the role of the RAS and its inhibition in solid tumor development.
  • To explore the potential of angiotensin II type I receptor (AT1R) inhibitors as chemopreventive agents for colorectal cancer.

Main Methods:

  • Review of preclinical studies on ANG II's effect on angiogenesis and proliferation.
  • Analysis of retrospective studies on RAS inhibitors and colorectal cancer incidence, polyp formation, and metastasis.
  • Examination of the impact of angiotensin-converting enzyme inhibitors (ACE-Is) on tumor development.

Main Results:

  • Preclinical data show ANG II stimulates angiogenesis and proliferation via VEGF.
  • RAS inhibition through AT1R blockade decreases solid tumor development and metastasis.
  • Retrospective analyses indicate reduced colorectal cancer incidence, polyps, and metastasis in patients using RAS inhibitors.

Conclusions:

  • RAS components are implicated in malignant tissue growth.
  • ACE inhibitors demonstrate potential as chemopreventive agents against colorectal cancer.
  • Further prospective trials are warranted to confirm the benefits of ACE-Is in colorectal cancer prevention.

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