Related Experiment Video

Updated: Apr 18, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.9K

Pleiotropic roles in cancer biology for multifaceted proteins FKBPs

Simona Romano1, Anna D'Angelillo2, Maria Fiammetta Romano1

  • 1Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy.

Biochimica Et Biophysica Acta
|January 17, 2015
PubMed
Abstract

Insights

FK506 binding proteins (FKBP) are crucial in cell signaling and cancer pathways. Some FKBPs promote cancer, while others offer protection, highlighting their complex roles in tumorigenesis.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Background:

  • FK506 binding proteins (FKBP) are highly conserved, multifunctional proteins involved in immunosuppression and modulating cellular signaling pathways.
  • FKBPs possess isomerase activity and interact with protein partners, influencing their conformation and function.
  • Emerging evidence indicates that FKBPs play a significant role in regulating cancer-related pathways.

Purpose of the Study:

  • To review current knowledge on the roles of FKBP family proteins in regulating key cancer-associated signaling pathways.
  • To consolidate understanding of FKBP involvement in cancer biology.

Main Methods:

  • Literature review of scientific articles and research data.
  • Analysis of existing studies on FKBP functions in cancer.
  • Synthesis of information on FKBP-mediated signaling in tumorigenesis.

Main Results:

  • FKBP proteins exhibit diverse roles in cancer, with some family members promoting tumor development.
  • Conversely, other FKBP members demonstrate protective effects against tumorigenesis.
  • The dual role of FKBPs in cancer necessitates a nuanced understanding of their specific functions.

Conclusions:

  • FKBP family proteins are implicated in both promoting and inhibiting cancer progression.
  • These proteins represent potential novel biomarkers for cancer diagnosis.
  • FKBPs are emerging as promising small molecular targets for future cancer therapies.
Keywords:
CancerFK506 binding proteinPeptidyl-prolyl-isomeraseTumorigenesis

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

949
Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.3K

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
8.0K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
3.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.8K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
12.2K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

6.6K