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Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats
Koichiro Homma1, Tadashi Yoshida, Maho Yamashita
1Department of Emergency and Critical Care Medicine School of Medicine, Keio University, Tokyo, Japan.
Nephron. Experimental Nephrology
|January 17, 2015
Summary
Hydrogen gas inhalation effectively reduces the severity of contrast-induced acute kidney injury (CIAKI) in rats. This novel antioxidant therapy alleviates kidney damage by decreasing apoptosis and oxidative stress.
Area of Science:
- Nephrology
- Biomedical Research
- Oxidative Stress
Background:
- Contrast-induced acute kidney injury (CIAKI) poses a significant clinical challenge.
- Investigating novel therapeutic strategies for CIAKI is crucial.
- Hydrogen (H₂) gas is a potential novel antioxidant for medical applications.
Purpose of the Study:
- To evaluate the efficacy of hydrogen (H₂) gas in mitigating CIAKI in a rat model.
- To explore the underlying mechanisms of H₂ gas in protecting against kidney injury.
Main Methods:
- CIAKI was induced in rats using Ioversol contrast medium and inhibitors of prostaglandin and nitric oxide synthesis.
- Rats inhaled either H₂ gas or a control gas during the induction procedure.
- Serum urea nitrogen, creatinine clearance, renal histology, apoptosis markers, and oxidative stress markers were assessed.
Main Results:
- H₂ gas inhalation significantly reduced serum urea nitrogen levels in CIAKI rats compared to controls.
- Creatinine clearance was improved in H₂ gas-treated rats.
- H₂ gas inhalation attenuated renal tubular necrosis, reduced apoptosis, and decreased oxidative stress markers.
Conclusions:
- Hydrogen (H₂) gas inhalation demonstrates a protective effect against CIAKI in a rat model.
- The therapeutic benefits of H₂ gas are attributed to its antioxidant properties, reducing apoptosis and oxidative stress in the kidneys.
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