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The emerging roles of YAP and TAZ in cancer

Toshiro Moroishi1, Carsten Gram Hansen1, Kun-Liang Guan1

  • 1Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

Nature Reviews. Cancer
|January 17, 2015
PubMed

Insights

The Hippo pathway

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • The Hippo pathway is crucial for regulating tissue homeostasis and organ size.
  • Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are key downstream effectors of this pathway.
  • Dysregulation of YAP and TAZ is implicated in various cancers.

Purpose of the Study:

  • To summarize the biological functions of YAP and TAZ.
  • To elucidate how YAP and TAZ regulation is disrupted in cancer.
  • To highlight the therapeutic potential of targeting YAP and TAZ in cancer treatment.

Main Methods:

  • Literature review of current research on YAP and TAZ.
  • Analysis of the role of YAP and TAZ in cancer progression.
  • Evaluation of YAP and TAZ as therapeutic targets.

Main Results:

  • YAP and TAZ play significant roles in tissue homeostasis, organ size, regeneration, and tumorigenesis.
  • Disrupted regulation of YAP and TAZ is a common feature in cancer development.
  • Emerging evidence points to the expanding role of YAP and TAZ in driving cancer progression.

Conclusions:

  • YAP and TAZ are critical regulators with implications in cancer biology.
  • Targeting YAP and TAZ presents a promising avenue for novel cancer therapies.
  • Further research is needed to fully exploit their therapeutic potential.

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