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Statins and brain integrity in older adults: secondary analysis of the Health ABC study
Neelesh K Nadkarni1, Subashan Perera1, Joseph T Hanlon2
1Division of Geriatric Medicine and Gerontology - Department of Medicine, University of Pittsburgh - School of Medicine, Pittsburgh, PA, USA.
Introduction:
We examined whether statins are associated with better cerebral white (WM) and gray matter (GM) indices in community-dwelling elders.
Methods:
In 295 older adults, we compared white matter hyperintensities (WMH) on brain magnetic resonance imaging and, total WM fractional anisotropy (FA) and GM mean diffusivity (MD) on diffusion tensor imaging, of Alzheimer's disease (AD) relevant regions in statin-exposed and statin-unexposed participants stratified by Modified Mini-Mental Status Examination (3MS) score.
Results:
There was no overall effect of statin exposure on cerebral structural indices. The interaction between statin exposure and 3MS was significant for total-WMH and WM FA (both P < .05) but not GM MD. In the lowest 3MS tertile (mean: 86), statin-exposed individuals had lower total-WMH and higher WM FA (P = .005 and P = .044) and FA of tracts linked to clinical AD (P-value range= .005-.04) despite statistical adjustments. These differences were not significant in the two higher 3MS tertiles.
Discussion:
Statins may benefit WM in older adults vulnerable to dementia.
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